Mitochondria in health, disease and aging - Winter School 2021

The mitochondrion in all its states... What happens when it does not work, when it does not provide the essential energy to our cells?

To answer these questions, international experts met in Nice from December 13 to 17, 2021 for a Winter School entitled: Mitochondria in health, disease and aging organized by the Graduate School LIFE (Université Côte d'Azur) as part of the IDEX program.

The conferences took place in the amphitheater "Le Galet", at the Pasteur Hospital, in the morning. This Winter School combined research and training with the intervention of experts in the field. Its objective: to stimulate reflection and exchange with national and international researchers who presented their work centered on mitochondrial functions and dysfunctions.

• Diagnose and manage a patient (child or adult) suffering from mitochondrial disease
• Understand the interest of new approaches (high throughput sequencing, functional studies...) to optimize the diagnosis of these diseases
• To address the issues of genetic counseling and methods of prenatal diagnosis of these diseases
• To understand the new mechanisms recently described as being at the origin of these diseases
   

Day 1 - December 13, 2021

• 9h30-10h30 : Metabolic reprogramming of mitochondria by proteolysis in aging and disease, Thomas Langer, Cologne, Germany
• 10h30-11h30 : Assessing mitochondrial morphology and its impact in health and disease, Tim Wai, Institut Pasteur, Paris

Day 2 - December 14, 2021

• 9h30-10h30 : Where in the mitochondrial network does protein synthesis occur ?, Robert Lightowlers, Newcastle, UK
• 10h30-11h30 : Premature aging mechanisms & mitochondria, Anu Suomalainen, Helsinki, Finland

Day 3 - December 15, 2021

• 9h30-10h30 : New physiopathological and therapeutic considerations on a mitochondrial blinding disease, Guy Lenaers, Angers
• 10h30-11h30 : Genome editing in mitochondria: past, present and future, Michal Minczuk, Cambridge, UK

Day 4 - December 16, 2021

• 9h30-10h30 : Mitochondrial medicine in the omics era, Shamima Rahman, London, UK
• 10h30-11h30 : Genetic diagnosis of mitochondrial diseases via RNA sequencing, Holger Prokisch, Munnich, Germany

Day 5 - December 17, 2021

• 9h30-10h30 : Mitochondrial dysfunction in motor neuron disease,Véronique Paquis-Flucklinger, Nice
• 10h30-11h30 : Maintaining a healthy mitochondrial pool via the NAD+-mitophagy axis as a therapeutic strategy for Alzheimer’s disease, Evandro Fei Fang, Lørenskog, Norway

Written test in terminal control